Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365772 | 0.86 | PRSS12 (0.37) | ALDH1A1SMN1; SMN2MAPTPRSS12TDP1 | |
| SCHEMBL7364343 | 0.85 | F2 (0.39) | MAPTTP53MEN1KMT2APOLB | |
| SCHEMBL7403972 | 0.83 | PLAU (0.44) | ALDH1A1SMN1; SMN2PRSS12TP53MEN1 | |
| SCHEMBL7502539 | 0.80 | PLAU (0.54) | ALDH1A1SMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL7403846 | 0.78 | LTA4H (0.38) | ALDH1A1TDP1L3MBTL1 | |
| SCHEMBL7406871 | 0.76 | POLB (0.52) | ALDH1A1MAPTTDP1L3MBTL1KDM4E | |
| SCHEMBL7400241 | 0.75 | PLAU (0.56) | ALDH1A1SMN1; SMN2MAPTTDP1L3MBTL1 | |
| SCHEMBL7399154 | 0.75 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPTTDP1L3MBTL1 | |
| SCHEMBL7403796 | 0.74 | PLAU (0.52) | ALDH1A1TDP1L3MBTL1KDM4EKMT2A | |
| SCHEMBL7389837 | 0.73 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2MAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |