Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406871 | 0.90 | POLB (0.52) | MAPTKMT2ANPC1MEN1ALDH1A1 | |
| SCHEMBL6436909 | 0.82 | DGAT2 (0.50) | MAPTSMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL7500900 | 0.80 | PLAU (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL7368790 | 0.77 | TAS1R3 (0.49) | — | |
| SCHEMBL7367423 | 0.76 | POLB (0.46) | MAPTKMT2ANPC1MEN1ALDH1A1 | |
| SCHEMBL7403061 | 0.75 | HPGD (0.43) | MAPTSMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL7403313 | 0.75 | GAA (0.48) | RAB9A | |
| SCHEMBL7368849 | 0.75 | ALDH1A1 (0.39) | MAPTSMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL6434389 | 0.74 | PTPRC (0.49) | MAPTKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL7407412 | 0.73 | PLAU (0.49) | SMN1; SMN2ALDH1A1MCL1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |