Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HCK | P08631 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370601 | 0.90 | SRC (0.46) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL7368033 | 0.87 | PIK3CD (0.50) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL7370561 | 0.86 | L3MBTL1 (0.47) | ALDH1A1KAT2BADORA1MAPTL3MBTL1 | |
| SCHEMBL7363887 | 0.84 | KAT2B (0.52) | KDRKDM4EALDH1A1HPGDKAT2B | |
| SCHEMBL13324084 | 0.83 | KDM4E (0.55) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL7369486 | 0.82 | KAT2B (0.49) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL7362432 | 0.81 | MKNK1 (0.44) | SRCPIK3CDABL1EGFRHCK | |
| SCHEMBL7365416 | 0.81 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDKAT2BADORA1 | |
| SCHEMBL7361949 | 0.80 | PDE4A (0.53) | KDM4EALDH1A1HPGDKAT2BMAPT | |
| SCHEMBL7366633 | 0.79 | NCOA1 (0.46) | ALDH1A1HPGDKAT2BADORA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |