Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367931 | 0.91 | HPGD (0.55) | KAT2BHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7371143 | 0.88 | KDM4E (0.53) | KAT2BHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7369486 | 0.87 | KAT2B (0.49) | KAT2BHPGDKDM4EPOLBMAPK1 | |
| SCHEMBL7362432 | 0.86 | MKNK1 (0.44) | KAT2BHPGDKDM4EPOLBMAPK1 | |
| SCHEMBL7366633 | 0.84 | NCOA1 (0.46) | KAT2BHPGDALDH1A1POLBKDM5B | |
| SCHEMBL7369403 | 0.84 | KDM4E (0.44) | KAT2BHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7369331 | 0.84 | SRC (0.46) | KAT2BHPGDALDH1A1KDM4EKDM5B | |
| SCHEMBL7364707 | 0.82 | HPGD (0.52) | KAT2BHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7370561 | 0.82 | L3MBTL1 (0.47) | KAT2BALDH1A1POLBMAPTL3MBTL1 | |
| SCHEMBL7363944 | 0.81 | ALDH1A1 (0.54) | KAT2BHPGDALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |