Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | TGM1 | P22735 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370605 | 0.91 | KDM4E (0.48) | KDM4EALDH1A1HPGDLMNAKAT2B | |
| SCHEMBL7365416 | 0.90 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDTBXAS1LMNA | |
| SCHEMBL7367898 | 0.87 | TBXAS1 (0.48) | KDM4EALDH1A1HPGDTBXAS1LMNA | |
| SCHEMBL7366890 | 0.86 | PDE4A (0.55) | KDM4EALDH1A1HPGDLMNATHRB | |
| SCHEMBL7372162 | 0.86 | RAB9A (0.51) | ALDH1A1TBXAS1TP53MAPTMEN1 | |
| SCHEMBL7361643 | 0.85 | PDE4A (0.54) | KDM4EALDH1A1HPGDLMNATHRB | |
| SCHEMBL7365662 | 0.84 | HPGD (0.55) | KDM4EALDH1A1HPGDTBXAS1LMNA | |
| SCHEMBL7370613 | 0.82 | HPGD (0.52) | KDM4EHPGDTBXAS1KAT2BTP53 | |
| SCHEMBL7369334 | 0.81 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDKAT2BTHRB | |
| SCHEMBL7361314 | 0.81 | TBXAS1 (0.46) | KDM4EHPGDTBXAS1TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |