Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16147216 | 0.82 | TBXAS1 (0.46) | TBXAS1ALDH1A1HSD17B10CYP4F2CYP4A11 | |
| SCHEMBL6635706 | 0.82 | KDM4E (0.46) | TBXAS1ALDH1A1HSD17B10KDM4ETSHR | |
| SCHEMBL7371527 | 0.82 | TBXAS1 (0.47) | TBXAS1CYP4F2CYP4A11CYSLTR2CYSLTR1 | |
| SCHEMBL7374705 | 0.80 | LMNA (0.49) | TBXAS1ALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL28696981 | 0.80 | KMT2A (0.39) | ALDH1A1HSD17B10KDM4EPOLBCYP3A4 | |
| SCHEMBL7378158 | 0.79 | TBXAS1 (0.41) | TBXAS1ALDH1A1CYP4F2CYP4A11CYSLTR2 | |
| SCHEMBL20477208 | 0.78 | CYP4F2 (0.48) | TBXAS1ALDH1A1HSD17B10CYP4F2CYP4A11 | |
| SCHEMBL27795170 | 0.78 | ALDH1A1 (0.49) | ALDH1A1HSD17B10KDM4EPOLBCYP3A4 | |
| SCHEMBL16147506 | 0.77 | CYP4F2 (0.43) | TBXAS1ALDH1A1HSD17B10CYP4F2CYP4A11 | |
| SCHEMBL7587819 | 0.76 | GRM4 (0.44) | ALDH1A1HSD17B10KDM4ETDP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| EP-0757670-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |