Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.34 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.34 |
| ▸ | ITGA8 | P53708 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367300 | 0.83 | ITGB3 (0.51) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7346389 | 0.83 | MAPT (0.35) | GAAMAPTITGB3ITGAVITGB6 | |
| SCHEMBL7345255 | 0.81 | ITGB3 (0.53) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7343261 | 0.81 | ITGB3 (0.40) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7346226 | 0.74 | LMNA (0.35) | GAAMAPTITGB3ITGAVITGB6 | |
| SCHEMBL7338522 | 0.72 | MAPT (0.34) | MAPTITGB3ITGAVITGB6ITGB1 | |
| SCHEMBL7338530 | 0.72 | MAPT (0.34) | MAPTITGB3ITGAVITGB6ITGB1 | |
| SCHEMBL7340934 | 0.71 | ITGB3 (0.37) | GAAMAPTITGB3ITGAVITGB1 | |
| SCHEMBL7345846 | 0.71 | ITGB3 (0.38) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7340943 | 0.71 | ITGB1 (0.34) | MAPTITGB3ITGAVITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | disclosed |