Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FOS | P01100 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373033 | 0.87 | HSD17B10 (0.41) | POLBHSD17B10GAAMAPTMTNR1A | |
| SCHEMBL21430976 | 0.84 | GAA (0.47) | HSD17B10GAAMAPTADRA1ATAAR1 | |
| SCHEMBL491188 | 0.82 | HSD17B10 (0.71) | POLBHSD17B10MTNR1AMTNR1BADRA1A | |
| SCHEMBL30436820 | 0.82 | HSD17B10 (0.71) | POLBHSD17B10MTNR1AMTNR1BADRA1A | |
| SCHEMBL21431072 | 0.79 | GAA (0.45) | HSD17B10GAAMAPTADRA1ATAAR1 | |
| SCHEMBL6720856 | 0.78 | NPSR1 (0.48) | KEAP1NPSR1FFAR1ALDH1A1 | |
| SCHEMBL7043778 | 0.78 | MTNR1A (0.45) | HSD17B10GAAMTNR1AMTNR1BHTT | |
| SCHEMBL22946300 | 0.77 | GAA (0.43) | HSD17B10GAAMAPTADRA1ATAAR1 | |
| SCHEMBL903987 | 0.77 | KDM4E (0.45) | POLBMAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL10909359 | 0.77 | POLB (0.60) | POLBHSD17B10PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000031-A4 | VITRONECTIN RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM CORP (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6239138-B1 | TREATMENT OF INFLAMMATION, CANCER, CARDIOVASCULAR DISORDERS, SUCH AS ATHEROSCLEROSIS AND RESTENOSIS, OSTEOPOROSIS, BENZOCYCLOHEPTENYL IN WHICH A NITROGEN-CONTAINING SUBSTITUENT IS PRESENT ON THE AROMATIC SIX-MEMBERED RING AND AN ALIPHATIC | SMITHKLINE BEECHAM CORPORATION | 2001-05-29 | — | — | US | disclosed |
| EP-1000031-A1 | VITRONECTIN RECEPTOR ANTAGONIST | SmithKline Beecham Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005107-A1 | VITRONECTIN RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-04 | — | — | WO | disclosed |