SCHEMBL491188

SCHEMBL491188

COc1ccc(OC)c(CCC(=O)O)c1

nearest known ligand 0.71

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.71
POLB P06746 1/20 0.67
ADRA1A P35348 1/20 0.60
TAAR1 Q96RJ0 1/20 0.60
MTNR1A P48039 1/20 0.58
MTNR1B P49286 1/20 0.58
AOC3 Q16853 1/20 0.54
IDO1 P14902 1/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30436820 1.00 HSD17B10 (0.71) HSD17B10POLBADRA1ATAAR1MTNR1A
SCHEMBL11433418 0.90 HSD17B10 (0.67) HSD17B10POLBADRA1ATAAR1MTNR1A
SCHEMBL27621740 0.89 HSD17B10 (0.65) HSD17B10POLBADRA1ATAAR1MTNR1A
SCHEMBL7332981 0.88 HSD17B10 (0.63) HSD17B10POLBADRA1ATAAR1MTNR1A
SCHEMBL10909359 0.88 POLB (0.60) HSD17B10POLBADRA1ATAAR1MTNR1A
SCHEMBL490637 0.87 POLB (0.71) HSD17B10POLB
SCHEMBL11077966 0.87 MTNR1A (0.62) HSD17B10POLBADRA1ATAAR1MTNR1A
SCHEMBL64208 0.85 MTNR1A (0.61) HSD17B10ADRA1ATAAR1MTNR1AMTNR1B
SCHEMBL7368806 0.85 POLB (0.79) HSD17B10POLBMTNR1AMTNR1B
SCHEMBL7190492 0.84 HSD17B10 (0.59) HSD17B10ADRA1ATAAR1MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116660543-A Diagnostic and prognostic markers for nonalcoholic fatty liver disease and uses thereof 中国人民解放军陆军军医大学第一附属医院 2023-08-29 CN claimed
WO-2024145483-A1 COMPOUNDS FOR USE IN THE TREATMENT OF CANCER AND METHODS OF MAKING AND USING THE SAME HTG MOLECULAR DIAGNOSTICS, INC. (US) 2024-07-04 WO disclosed
CN-116077553-B Dressing containing walnut shell extract for promoting wound healing and preparation method thereof 西安交通大学 2024-05-24 CN disclosed
US-20240166618-A1 PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME GILGAMESH PHARMACEUTICALS, INC. (US) 2024-05-23 US disclosed
CN-117642379-A Phenylalkylamines and methods of making and using the same 吉尔伽美什制药公司 2024-03-01 CN disclosed
CN-116077553-A Application of walnut shell extract in promoting wound healing, wound dressing based on walnut shell extract and preparation method of wound dressing 西安交通大学 2023-05-09 CN disclosed
US-11253596-B2 Phenylalkylcarboxylic acid delivery agents NOVO NORDISK NORTH AMERICA OPERATIONS A/S (DK) 2022-02-22 US disclosed
US-20200405863-A1 PHENYLALKYLCARBOXYLIC ACID DELIVERY AGENTS NOVO NORDISK A/S (DK) 2020-12-31 US disclosed
US-10456472-B2 Phenylalkylcarboxylic acid delivery agents EMISPHERE TECHNOLOGIES, INC. (US) 2019-10-29 US disclosed
EP-2114145-B1 PHENYLALKYLCARBOXYLIC ACID DELIVERY AGENTS EMISPHERE TECH INC (US) 2017-11-01 EP disclosed
EP-1061919-A4 NOVEL OPIATE COMPOUNDS, METHODS OF MAKING AND METHODS OF USE RES TRIANGLE INST (US) 2002-09-04 EP disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
EP-1061919-A1 NOVEL OPIATE COMPOUNDS, METHODS OF MAKING AND METHODS OF USE Carrol, Frank Ivy (US) 2000-12-27 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed
WO-1999045925-A1 NOVEL OPIATE COMPOUNDS, METHODS OF MAKING AND METHODS OF USE RESEARCH TRIANGLE INSTITUTE (US) 1999-09-16 WO disclosed
US-5087671-A Insoluble polymers containing reactive groups THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 1992-02-11 US disclosed
US-5066658-A Enzyme Inhibitors; Bronchodilators; Antiinflammatory Agents ORTHO PHARMACEUTICAL CORPORATION (US) 1991-11-19 US disclosed
US-4231950-A PHOTOGRAPHY POLAROID CORPORATION (US) 1980-11-04 US disclosed
US-4206139-A Synthesis of benzaldehydes POLAROID CORPORATION (US) 1980-06-03 US disclosed
US-4166741-A FOR SELF-DEVELOPING PHOTOGRAPHIC FILMS POLAROID CORPORATION (US) 1979-09-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200405863-A1 PHENYLALKYLCARBOXYLIC ACID DELIVERY AGENTS PGF, LIPA, PDGFA HSD17B10 1647/4885POLB 3555/4885ADRA1A 2293/4885
US-20240166618-A1 PHENALKYLAMINES AND METHODS OF MAKING AND USING THE SAME PNMT, HTR6, HTR2C HSD17B10 917/4885POLB 1731/4885ADRA1A 640/4885
US-10456472-B2 Phenylalkylcarboxylic acid delivery agents PGF, LIPA, PDGFA HSD17B10 1647/4885POLB 3555/4885ADRA1A 2293/4885
US-11253596-B2 Phenylalkylcarboxylic acid delivery agents PGF, LIPA, PDGFA HSD17B10 1647/4885POLB 3555/4885ADRA1A 2293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.