Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.57 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367644 | 0.89 | GAA (0.64) | GAAKDM4EPOLBNPC1SMN1; SMN2 | |
| SCHEMBL7368408 | 0.89 | HSD17B1 (0.58) | GAAHSD17B2HSD17B1POLBNPC1 | |
| SCHEMBL7371083 | 0.86 | HTT (0.56) | GAAPOLBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL7376298 | 0.86 | L3MBTL1 (0.48) | GAAHSD17B2HSD17B1POLBNPC1 | |
| SCHEMBL7378335 | 0.85 | CHRNB2 (0.52) | GAAPOLBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL7377757 | 0.81 | MAPT (0.52) | GAAKDM4EPOLBNPC1SMN1; SMN2 | |
| SCHEMBL7517678 | 0.81 | NPC1 (0.47) | GAAPOLBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL7375535 | 0.80 | L3MBTL1 (0.50) | GAAPOLBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL7374859 | 0.80 | NAMPT (0.52) | GAAKDM4EPOLBNPC1RAB9A | |
| SCHEMBL7379111 | 0.79 | POLB (0.52) | GAAPOLBNPC1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |