SCHEMBL7370235

SCHEMBL7370235

CN(C=O)c1cccc(N)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.42
CASP1 P29466 1/20 0.42
RECQL P46063 1/20 0.42
SIGMAR1 Q99720 1/20 0.38
ALDH1A1 P00352 6/20 0.36
LMNA P02545 1/20 0.36
CA12 O43570 2/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA9 Q16790 2/20 0.35
CA14 Q9ULX7 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
CA7 P43166 1/20 0.35
MAOA P21397 2/20 0.35
CYP19A1 P11511 2/20 0.35
FGFR1 P11362 1/20 0.35
KDR P35968 1/20 0.35
MAOB P27338 1/20 0.35
CA4 P22748 1/20 0.35
CLK1 P49759 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28308085 0.83 ACHE (0.39) CYP3A4CASP1RECQLSIGMAR1ALDH1A1
SCHEMBL28874617 0.79 CYP3A4 (0.46) CYP3A4CASP1RECQLALDH1A1LMNA
SCHEMBL9817314 0.78 CYP3A4 (0.44) CYP3A4CASP1RECQLALDH1A1LMNA
SCHEMBL2095103 0.78 HSD17B1 (0.46) CYP3A4RECQLSIGMAR1ALDH1A1LMNA
SCHEMBL8883643 0.77 ALOX15 (0.41) CYP3A4CASP1RECQLALDH1A1LMNA
SCHEMBL11503532 0.76 CYP3A4 (0.52) CYP3A4CASP1RECQLSIGMAR1ALDH1A1
SCHEMBL374790 0.76 ALDH1A1 (0.54) CYP3A4CASP1RECQLSIGMAR1ALDH1A1
SCHEMBL29647628 0.76 ALDH1A1 (0.54) CYP3A4CASP1RECQLSIGMAR1ALDH1A1
SCHEMBL2089356 0.76 ACHE (0.40) CYP3A4
SCHEMBL2096476 0.76 APP (0.43) SIGMAR1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6410529-B1 DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2002-06-25 US disclosed
EP-1003737-A1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-05-31 EP disclosed
WO-2000007993-A1 SUBSTITUTED ISOQUINOLEINES AND THEIR USE AS ANTICONVULSIVANTS SMITHKLINE BEECHAM PLC (GB) 2000-02-17 WO disclosed
WO-1999009024-A1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS HFGAN72 ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-02-25 WO disclosed