SCHEMBL7370428

SCHEMBL7370428

COc1ccc(CN)cc1OCC(=O)N1CCN(Cc2ccccc2)CC1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2C9 P11712 1/20 0.62
KDM4E B2RXH2 5/20 0.56
KMT2A Q03164 4/20 0.56
MEN1 O00255 3/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
LMNA P02545 3/20 0.56
TSHR P16473 1/20 0.56
MAPK1 P28482 2/20 0.55
TP53 P04637 1/20 0.55
FAAH O00519 1/20 0.55
HSD17B10 Q99714 1/20 0.54
CACNA1F O60840 1/20 0.53
ADORA3 P0DMS8 1/20 0.53
OPRM1 P35372 1/20 0.53
OPRK1 P41145 1/20 0.53
CACNA1D Q01668 1/20 0.53
CACNA1S Q13698 1/20 0.53
CACNA1C Q13936 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7370205 0.92 CCR1 (0.56) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A
SCHEMBL7369950 0.92 KDM4E (0.55) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A
SCHEMBL8545193 0.91 KDM4E (0.54) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A
SCHEMBL7373089 0.89 CACNA1F (0.55) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A
SCHEMBL7370866 0.88 KDM4E (0.58) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A
SCHEMBL5063868 0.87 CCR1 (0.56) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A
SCHEMBL7372505 0.87 CACNA1F (0.53) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A
SCHEMBL7366950 0.84 SMN1; SMN2 (0.55) ALDH1A1KDM4EKMT2AMEN1SMN1; SMN2
SCHEMBL7373261 0.84 ALDH1A1 (0.49) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A
SCHEMBL5056246 0.84 ALDH1A1 (0.69) ALDH1A1CYP3A4CYP2C9KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5929074-A VSODILATOR, ANTIALLERGIC AND ANTIPLATELET AGENTS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1999-07-27 US disclosed
EP-0706517-B1 PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY NISSAN CHEMICAL IND LTD (JP) 1998-10-21 EP disclosed
US-5728702-A BRONCHODILATOR AGENTS, ANTIALLERGENS OR ANTIPLATELET DRUGGS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-17 US disclosed
EP-0706517-A1 PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1996-04-17 EP disclosed
WO-1995001343-A1 PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1995-01-12 WO disclosed