Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374468 | 0.90 | KDM4E (0.49) | KDM4EALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL7370428 | 0.88 | ALDH1A1 (0.62) | KDM4EALDH1A1CYP3A4CYP2C9MEN1 | |
| SCHEMBL7370205 | 0.84 | CCR1 (0.56) | KDM4EALDH1A1CYP3A4CYP2C9MEN1 | |
| SCHEMBL7369950 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1CYP3A4CYP2C9MEN1 | |
| SCHEMBL8545193 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1CYP3A4CYP2C9MEN1 | |
| SCHEMBL7375943 | 0.83 | KDM4E (0.52) | KDM4EALDH1A1CYP3A4CYP2C9MEN1 | |
| SCHEMBL5063868 | 0.80 | CCR1 (0.56) | KDM4EALDH1A1CYP3A4CYP2C9MEN1 | |
| SCHEMBL7366950 | 0.79 | SMN1; SMN2 (0.55) | KDM4EALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL7373261 | 0.79 | ALDH1A1 (0.49) | KDM4EALDH1A1CYP3A4CYP2C9MEN1 | |
| SCHEMBL7373089 | 0.78 | CACNA1F (0.55) | KDM4EALDH1A1CYP3A4CYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706517-B1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL IND LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0706517-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001343-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |