SCHEMBL7370588

SCHEMBL7370588

O=C(O)CCC(=O)NC(Cc1ccccc1)CP(=O)(O)O

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MME P08473 10/20 0.59
ACE P12821 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7369309 0.92 MME (0.72) MMEACE
SCHEMBL7365324 0.88 MME (0.66) MMEACE
SCHEMBL7366443 0.82 MME (0.51) MMEACE
SCHEMBL7359942 0.81 CTRB1 (0.50) MME
SCHEMBL7367862 0.79 MME (0.54) MMEACE
SCHEMBL7363022 0.78 CTRB1 (0.52) MME
SCHEMBL7443024 0.77 PIN1 (0.49) MME
SCHEMBL7363566 0.77 PIN1 (0.59) ACE
SCHEMBL7363491 0.76 TAAR1 (0.59)
SCHEMBL7367157 0.76 NAALAD2 (0.58) MME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0117429-B1 PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES SCHERING CORPORATION (US) 1987-09-02 EP claimed
EP-0117429-B1 PHOSPHOROUS CONTAINING COMPOUNDS AS INHIBITORS OF ENKEPHALINASES SCHERING CORPORATION (US) 1987-09-02 EP disclosed
EP-0117429-A1 Phosphorous containing compounds as inhibitors of enkephalinases SCHERING CORPORATION (US) 1984-09-05 EP disclosed