Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370600 | 0.90 | MEN1 (0.51) | RAB9AL3MBTL1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7370618 | 0.90 | RAB9A (0.51) | RAB9ATBXAS1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL7365028 | 0.86 | KDM4E (0.50) | TBXAS1ALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL7370613 | 0.85 | HPGD (0.52) | RAB9ATBXAS1MAPTSMN1; SMN2PDE4A | |
| SCHEMBL7366591 | 0.85 | ALDH1A1 (0.59) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7364065 | 0.84 | PDE4A (0.57) | RAB9AL3MBTL1ALDH1A1SMN1; SMN2PDE4A | |
| SCHEMBL7361314 | 0.84 | TBXAS1 (0.46) | RAB9ATBXAS1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7365662 | 0.82 | HPGD (0.55) | TBXAS1ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7367402 | 0.82 | NCOA1 (0.46) | RAB9ATBXAS1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7364120 | 0.80 | TBXAS1 (0.50) | RAB9ATBXAS1L3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |