Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPN | P05981 | 1/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364282 | 0.94 | ALOX15 (0.41) | HSD17B10ALOX15USP2GAACTSL | |
| SCHEMBL7364536 | 0.90 | F10 (0.44) | HSD17B10ALOX15HPNST14BACE1 | |
| SCHEMBL7163736 | 0.89 | TDP1 (0.53) | HSD17B10ALOX15USP2GAASMN1; SMN2 | |
| SCHEMBL7365336 | 0.87 | TSHR (0.43) | HSD17B10ALOX15SMN1; SMN2TP53POLB | |
| SCHEMBL7370120 | 0.86 | HSD17B10 (0.41) | HSD17B10ALOX15USP2GAASMN1; SMN2 | |
| SCHEMBL7364374 | 0.86 | ITGB3 (0.44) | HSD17B10SMN1; SMN2TP53POLBTSHR | |
| SCHEMBL7165857 | 0.85 | MMP2 (0.47) | HSD17B10ALOX15USP2GAAPOLB | |
| SCHEMBL7374002 | 0.85 | SMN1; SMN2 (0.45) | HSD17B10ALOX15USP2GAASMN1; SMN2 | |
| SCHEMBL7366599 | 0.84 | ITGB3 (0.41) | HSD17B10ALOX15USP2GAATHRB | |
| SCHEMBL7367335 | 0.83 | GAA (0.40) | HSD17B10ALOX15USP2GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964856-B1 | BICYCLIC AMINO ACIDS | MERCK PATENT GMBH (DE) | 2002-10-09 | — | — | EP | disclosed |
| EP-0964856-A1 | BICYCLIC AMINO ACIDS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998035949-A1 | BICYCLIC AMINO ACIDS | MERCK PATENT GMBH (DE) | 1998-08-20 | — | — | WO | disclosed |