Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30286022 | 0.84 | POLB (0.49) | LMNATSHRKMT2AMEN1MAPT | |
| SCHEMBL7403833 | 0.81 | ADRB2 (0.44) | LMNATSHRTDP1KMT2AMEN1 | |
| SCHEMBL15068128 | 0.80 | TSHR (0.53) | LMNATSHRTDP1KMT2AMEN1 | |
| SCHEMBL5987876 | 0.80 | KMT2A (0.42) | LMNATDP1KMT2AMEN1CYP3A4 | |
| SCHEMBL7366509 | 0.79 | KMT2A (0.53) | TSHRKMT2AMAPTALDH1A1POLB | |
| SCHEMBL1804701 | 0.78 | NPC1 (0.58) | KMT2AMEN1MAPTALDH1A1POLB | |
| SCHEMBL6822002 | 0.77 | ALDH1A1 (0.52) | KMT2AMEN1CYP3A4MAPTALDH1A1 | |
| SCHEMBL10665226 | 0.77 | LMNA (0.49) | LMNATSHRTDP1KMT2AMEN1 | |
| SCHEMBL7425083 | 0.77 | ALDH1A1 (0.57) | LMNATSHRTDP1KMT2AMEN1 | |
| SCHEMBL4588943 | 0.76 | TDP1 (0.58) | LMNATSHRTDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999026932-A1 | BY AMIDINO GROUP SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |