Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15296872 | 0.87 | POLB (0.53) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL7364876 | 0.84 | ABCB1 (0.46) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL12212607 | 0.81 | KDM4E (0.59) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL10838063 | 0.80 | HIF1A (0.51) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL10836817 | 0.78 | LMNA (0.49) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL258823 | 0.76 | HIF1A (0.75) | LMNAPOLBHIF1ACYP2D6ADRB2 | |
| SCHEMBL11273462 | 0.76 | LMNA (0.59) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL7336029 | 0.76 | POLB (0.47) | LMNAMAPK1POLBHIF1AMEN1 | |
| SCHEMBL11842298 | 0.75 | HTR2A (0.47) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL11882594 | 0.74 | MAPK1 (0.63) | LMNAKDM4EMAPK1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994002463-A1 | ANTIHYPERTENSIVE 1,4-DIHYDROPYRIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-02-03 | — | — | WO | disclosed |