Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12212607 | 0.84 | KDM4E (0.59) | LMNAKDM4EMAPK1POLBCYP2D6 | |
| SCHEMBL10838063 | 0.82 | HIF1A (0.51) | LMNAKDM4EMAPK1POLBCYP2D6 | |
| SCHEMBL15296872 | 0.81 | POLB (0.53) | LMNAKDM4EMAPK1POLBCYP2D6 | |
| SCHEMBL258823 | 0.78 | HIF1A (0.75) | LMNAPOLBCYP2D6ADRB2ADRB1 | |
| SCHEMBL11273462 | 0.78 | LMNA (0.59) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL7370828 | 0.78 | LMNA (0.47) | LMNAKDM4EMAPK1POLBCYP2D6 | |
| SCHEMBL19648494 | 0.78 | MEN1 (0.57) | LMNAMAPK1POLBMEN1KMT2A | |
| SCHEMBL6264190 | 0.75 | HIF1A (0.57) | LMNAKDM4EPOLBCYP2D6ADRB2 | |
| SCHEMBL11438620 | 0.75 | CHRNB2 (0.58) | LMNAKDM4EMAPK1POLBHIF1A | |
| SCHEMBL16090435 | 0.75 | ADRB1 (0.70) | LMNAKDM4ECYP2D6ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4608383-A | Cardioactive pyrazole and imidazole aryloxypropanolamines | BOEHRINGER MANNHEIM GMBH (DE) | 1986-08-26 | — | — | US | disclosed |
| EP-0042593-B1 | ARYLOXY-PROPANOL AMINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1985-04-03 | — | — | EP | disclosed |
| US-4438128-A | ADRENERGIC BLOCKERS | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |
| EP-0042593-A1 | Aryloxy-propanol amines, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1981-12-30 | — | — | EP | disclosed |