Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27674584 | 0.91 | CYP11B1 (0.49) | CYP11B1CYP11B2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7370892 | 0.86 | NPY5R (0.57) | CYP11B1CYP11B2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7369697 | 0.84 | NPY5R (0.54) | CYP11B1CYP11B2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7376655 | 0.84 | MGAM (0.52) | CYP11B1CYP11B2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7369715 | 0.84 | CYP11B1 (0.52) | CYP11B1CYP11B2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7372656 | 0.82 | ALOX5 (0.50) | CYP11B1CYP11B2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL27692933 | 0.82 | CYP11B1 (0.50) | CYP11B1CYP11B2KDM4EMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7369410 | 0.81 | PDE5A (0.58) | CYP11B1CYP11B2MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7372422 | 0.81 | NPY5R (0.57) | CYP11B1CYP11B2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7372737 | 0.79 | MGAM (0.52) | CYP11B1CYP11B2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| CN-87105680-A | Imidazolium compounds and preparation method thereof and comprise the pharmaceutical composition of this compound | — | 1988-04-27 | — | — | CN | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |