SCHEMBL7370889

SCHEMBL7370889

c1ccc(C[C](c2ccccc2Cc2ccccc2)C2CC2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 1/20 0.44
SCN2A Q99250 1/20 0.44
SCN3A Q9NY46 1/20 0.44
TSHR P16473 2/20 0.42
CYP2D6 P10635 2/20 0.40
CYP2C19 P33261 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP3A4 P08684 1/20 0.39
BCL2 P10415 1/20 0.39
BCL2L1 Q07817 1/20 0.39
LMNA P02545 1/20 0.39
AKR1B1 P15121 1/20 0.38
HRH1 P35367 1/20 0.38
CAPN1 P07384 1/20 0.38
HTR2A P28223 1/20 0.37
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7446846 0.83 TSHR (0.39) SCN1ASCN2ASCN3ATSHRCYP2D6
SCHEMBL7435318 0.83 SCN1A (0.38) SCN1ASCN2ASCN3ATSHRCYP2D6
SCHEMBL7439021 0.81 SCN1A (0.36) SCN1ASCN2ASCN3ATSHRCYP2D6
SCHEMBL7432308 0.79 SCN1A (0.37) SCN1ASCN2ASCN3ATSHRCYP2D6
SCHEMBL7446176 0.76 ALDH1A1 (0.40) CYP2D6LMNAALDH1A1GLAHPGD
SCHEMBL8669232 0.74 AKR1B1 (0.46) LMNAAKR1B1HTR2AMEN1KMT2A
SCHEMBL7441986 0.74 ALDH1A1 (0.40) CYP2D6LMNAAKR1B1MEN1KMT2A
SCHEMBL9132381 0.74 TSHR (0.44) TSHRLMNAAKR1B1KDM4EL3MBTL1
SCHEMBL9132564 0.73 SCN1A (0.41) SCN1ASCN2ASCN3ATSHRCYP2D6
SCHEMBL9131019 0.72 TSHR (0.41) TSHRLMNAKDM4EALDH1A1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0691961-A1 SUBSTITUTED CAPROLACTAMS AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF HIV DISEASE THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-01-17 EP disclosed
WO-1994008977-A1 SUBSTITUTED CAPROLACTAMS AND DERIVATIVES THEREOF USEFUL FOR TREATMENT OF AIDS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-04-28 WO disclosed