Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10354233 | 0.78 | HTR6 (0.62) | AKR1B1HTR6AGTR1ALDH1A1KDM4E | |
| SCHEMBL7363629 | 0.76 | AGTR1 (0.49) | AKR1B1HTR6AGTR1HSD11B1ALDH1A1 | |
| SCHEMBL4591949 | 0.73 | PKM (0.42) | ALDH1A1LMNAHTTCA12CA1 | |
| SCHEMBL5763922 | 0.72 | CXCR2 (0.33) | HSD11B1ALDH1A1LMNAADORA2AADORA1 | |
| SCHEMBL4150360 | 0.72 | HTR6 (0.54) | HTR6HSD11B1ALDH1A1MAPTHTT | |
| SCHEMBL6206045 | 0.71 | LMNA (0.47) | AKR1B1HTR6ALDH1A1MAPTLMNA | |
| SCHEMBL16872329 | 0.69 | PDE4A (0.40) | ADORA2AADORA1PDE4APDE4CPDE4D | |
| SCHEMBL29407474 | 0.69 | PDE4A (0.40) | ADORA2AADORA1PDE4APDE4CPDE4D | |
| SCHEMBL7301533 | 0.68 | GAA (0.53) | AKR1B1HTR6AGTR1ALDH1A1KDM4E | |
| SCHEMBL25406591 | 0.68 | PDE4A (0.40) | LMNAHTTS1PR4S1PR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244669-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001040230-A1 | PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-06-07 | — | — | WO | disclosed |