SCHEMBL7373142

SCHEMBL7373142

Cc1cc(C(=O)O)nnn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 6/20 0.43
DAO P14920 1/20 0.43
ALDH1A1 P00352 4/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPK1 P28482 1/20 0.41
ALOX15 P16050 2/20 0.39
TSHR P16473 2/20 0.39
HIF1A Q16665 1/20 0.39
GPR35 Q9HC97 2/20 0.36
KDM4E B2RXH2 6/20 0.36
TDP1 Q9NUW8 3/20 0.36
ACMSD Q8TDX5 1/20 0.36
TPMT P51580 1/20 0.36
HCAR3 P49019 1/20 0.35
MAPT P10636 2/20 0.34
KDM6B O15054 1/20 0.34
TET3 O43151 1/20 0.34
KDM4A O75164 1/20 0.34
BBOX1 O75936 1/20 0.34
KDM5A P29375 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23819352 0.82 ALOX15 (0.48) HCAR2DAOALDH1A1SMN1; SMN2ALOX15
Phosphoric Acid SCHEMBL30490531 0.73 CYTH3 (0.45) HCAR2DAOALDH1A1SMN1; SMN2ALOX15
SCHEMBL20928641 0.73 ALOX15 (0.41) HCAR2DAOALDH1A1SMN1; SMN2ALOX15
SCHEMBL14008127 0.73
SCHEMBL1760306 0.70 KMO (0.49) HCAR2DAOALDH1A1SMN1; SMN2MAPK1
SCHEMBL1671322 0.70 KMO (0.50) HCAR2DAOALDH1A1SMN1; SMN2KDM4E
SCHEMBL13769258 0.68 ALDH1A1 (0.47) HCAR2DAOALDH1A1SMN1; SMN2MAPK1
SCHEMBL4288196 0.67 SMN1; SMN2 (0.46) HCAR2DAOALDH1A1SMN1; SMN2MAPK1
SCHEMBL1179028 0.67 ALDH1A1 (0.55) HCAR2DAOALDH1A1SMN1; SMN2MAPK1
SCHEMBL2718066 0.67 GAA (0.47) HCAR2DAOALDH1A1SMN1; SMN2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5849693-A Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein IIb/IIIa THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1998-12-15 US disclosed
US-5773411-A CARDIOVASCULAR DISORDERS AND BRAIN DISORDERS AND COAGULANTS THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1998-06-30 US disclosed
US-5691329-A Compounds containing basic and acidic termini useful as fibrinogen receptor antagonists THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1997-11-25 US disclosed
US-5563158-A CARDIOVASCULAR DISORDERS THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1996-10-08 US disclosed
WO-1995018111-A1 COMPOUNDS CONTAINING BASIC AND ACIDIC TERMINI USEFUL AS FIBRINOGEN RECEPTOR ANTAGONISTS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-07-06 WO disclosed
WO-1994011398-A1 CYCLIC COMPOUNDS LINKED BY A HETEROCYCLIC RING USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-05-26 WO disclosed