Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL7373673

NC(=O)[C@]1(Cc2cccc3nc(N)ccc23)CCNC1=O.O=C(O)C(F)(F)F

nearest known ligand 0.32

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.32
NCF1 P14598 6/20 0.32
CYBB P04839 2/20 0.32
CYP2D6 P10635 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
NOX5 Q96PH1 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL7374306 0.82 NOS1 (0.42)
Trifluoroacetic Acid SCHEMBL7369846 0.81 CYBB (0.34) BACE1NCF1CYBB
Trifluoroacetic Acid SCHEMBL7477240 0.72 MAP4K4 (0.36)
Trifluoroacetic Acid SCHEMBL7384671 0.70 NOS1 (0.37)
Trifluoroacetic Acid SCHEMBL7375571 0.70 ALDH1A1 (0.34)
Trifluoroacetic Acid SCHEMBL23412689 0.68 BACE1 (0.47) BACE1NCF1CYBBNOX5L3MBTL1
SCHEMBL7375448 0.67 NCF1 (0.32) BACE1NCF1CYBBNOX5
Trifluoroacetic Acid SCHEMBL7213069 0.66 F10 (0.36) BACE1NCF1CYBB
Trifluoroacetic Acid SCHEMBL7375613 0.65 NOS1 (0.41)
Trifluoroacetic Acid SCHEMBL7214007 0.65 F2 (0.38) BACE1NCF1CYBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086099-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2002-01-02 EP disclosed
EP-0944386-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2001-04-11 EP disclosed
EP-1086099-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS Aventis Pharmaceuticals Products Inc. (US) 2001-03-28 EP disclosed
WO-1999062904-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-12-09 WO disclosed
EP-0944386-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1999-09-29 EP disclosed
WO-1998025611-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS RHÔNE-POULENC RORER PHARMACEUTICALS INC. (US) 1998-06-18 WO disclosed