SCHEMBL7374064

SCHEMBL7374064

COc1ccccc1NC(=O)c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.78

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.78
KMT2A Q03164 5/20 0.78
RORC P51449 1/20 0.66
NPC1 O15118 1/20 0.66
MAPT P10636 3/20 0.65
ALDH1A1 P00352 2/20 0.65
ABCG2 Q9UNQ0 1/20 0.62
MLYCD O95822 1/20 0.61
SNCA P37840 1/20 0.61
PABPC1 P11940 1/20 0.59
APOBEC3A P31941 1/20 0.59
EIF4H Q15056 1/20 0.59
APOBEC3G Q9HC16 1/20 0.59
AHR P35869 1/20 0.58
MAOB P27338 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7748386 0.85 KMT2A (0.67) MEN1KMT2ANPC1MAPTALDH1A1
SCHEMBL13561219 0.84 MEN1 (0.76) MEN1KMT2AMAPTALDH1A1
SCHEMBL3528493 0.84 EPHX1 (0.78) MEN1KMT2ANPC1MAPTALDH1A1
SCHEMBL29886513 0.84 EPHX1 (0.78) MEN1KMT2ANPC1MAPTALDH1A1
SCHEMBL8308004 0.83 MEN1 (0.69) MEN1KMT2AMAPTALDH1A1
SCHEMBL2033537 0.83 MEN1 (0.74) MEN1KMT2AMAPTALDH1A1
SCHEMBL4254980 0.83 TP53 (0.75) MEN1KMT2AMAPTALDH1A1SNCA
SCHEMBL8713312 0.83 MEN1 (0.81) MEN1KMT2ANPC1MAPTALDH1A1
Iodide SCHEMBL30758664 0.83 EPHX1 (0.77) MEN1KMT2ANPC1MAPTALDH1A1
SCHEMBL13265686 0.83 MEN1 (0.65) MEN1KMT2ARORCMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP claimed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US claimed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP claimed
US-9023340-B2 Wnt inhibitors for human stem cell differentiation CHEMREGEN, INC. (US) 2015-05-05 US disclosed
CN-102224423-B Ligands for aggregated tau molecules WISTA LABORATORIES LTD. (SG) 2014-10-22 CN disclosed
US-20130177535-A1 WNT INHIBITORS FOR HUMAN STEM CELL DIFFERENTIATION CHEMREGEN, INC 2013-07-11 US disclosed
US-6211242-B1 CARDIOVASCULAR DISORDERS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-04-03 US disclosed
EP-0757670-B1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 1999-01-13 EP disclosed
US-5728835-A HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS TOA EIYO, LTD. (JP) 1998-03-17 US disclosed
EP-0757670-A1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-02-12 EP disclosed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP disclosed
WO-1995029152-A1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-11-02 WO disclosed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US disclosed
EP-0661266-A1 Substituted cyclic amine compounds as 5HT2 antagonists TOA EIYO LTD. (JP) 1995-07-05 EP disclosed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130177535-A1 WNT INHIBITORS FOR HUMAN STEM CELL DIFFERENTIATION WNT3A, WNT1, WNT3 MEN1 2567/4885KMT2A 2473/4885RORC 334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.