Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 12/20 | 0.71 |
| ▸ | HSD17B2 | P37059 | 12/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241029 | 0.89 | HSD17B1 (0.83) | HSD17B1HSD17B2KDM4ELMNATSHR | |
| SCHEMBL18585406 | 0.87 | HSD17B1 (0.53) | HSD17B1HSD17B2KDM4ELMNAHTT | |
| SCHEMBL29940968 | 0.85 | HSD17B2 (0.72) | HSD17B1HSD17B2KDM4ELMNATSHR | |
| SCHEMBL10212283 | 0.85 | HSD17B2 (0.72) | HSD17B1HSD17B2KDM4ELMNATSHR | |
| SCHEMBL21620298 | 0.84 | HSD17B1 (0.71) | HSD17B1HSD17B2LMNANPC1 | |
| SCHEMBL94811 | 0.84 | HSD17B1 (0.71) | HSD17B1HSD17B2SIGMAR1KDM4ELMNA | |
| SCHEMBL7368760 | 0.83 | HTR3E (0.54) | HSD17B1HSD17B2KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL4658072 | 0.82 | HSD17B1 (0.68) | HSD17B1HSD17B2HTT | |
| SCHEMBL7373511 | 0.82 | KMT2A (0.64) | KDM4ENPC1HTT | |
| SCHEMBL7376609 | 0.81 | HSD17B2 (0.75) | HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211242-B1 | CARDIOVASCULAR DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0757670-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-01-13 | — | — | EP | disclosed |
| EP-0757670-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029152-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |