Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ATR | Q13535 | 3/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367135 | 0.88 | CYP11B1 (0.52) | ABL1PDGFRBBCRPDGFRACYP11B1 | |
| SCHEMBL7372935 | 0.85 | ALDH1A1 (0.58) | ABL1PDGFRBBCRPDGFRAALDH1A1 | |
| SCHEMBL7376096 | 0.78 | KDM4E (0.49) | CYP11B1CYP11B2ALDH1A1HPGDRAB9A | |
| SCHEMBL7372373 | 0.77 | ALDH1A1 (0.59) | ABL1PDGFRBBCRPDGFRACYP11B1 | |
| SCHEMBL7371087 | 0.76 | NPC1 (0.43) | ABL1PDGFRBBCRPDGFRACYP11B2 | |
| SCHEMBL7370057 | 0.75 | LMNA (0.43) | ABL1BCRATRKDM4E | |
| SCHEMBL10566233 | 0.74 | CYP11B1 (0.45) | ABL1PDGFRBBCRPDGFRACYP11B1 | |
| SCHEMBL7369586 | 0.73 | ROS1 (0.47) | CYP11B1CYP11B2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL7366286 | 0.73 | ABCB1 (0.49) | ALDH1A1RAB9ANPC1ATRMAPT | |
| SCHEMBL7368714 | 0.72 | IKBKB (0.48) | CYP11B1CYP11B2ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |