Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376096 | 0.88 | KDM4E (0.49) | IKBKBCYP11B2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7368966 | 0.85 | NPC1 (0.46) | CYP11B2SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL7372407 | 0.85 | LMNA (0.49) | CYP11B2SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL28943489 | 0.84 | USP1 (0.46) | CYP11B2 | |
| SCHEMBL7373136 | 0.83 | POLB (0.51) | CYP11B2SMN1; SMN2NPC1KDM4ECYP11B1 | |
| SCHEMBL7374180 | 0.82 | NPY5R (0.47) | CYP11B2SMN1; SMN2KDM4EHPGDCYP11B1 | |
| SCHEMBL7372593 | 0.81 | DHFR (0.43) | CYP11B2KDM4EHPGDTSHRCYP11B1 | |
| SCHEMBL7376110 | 0.80 | ADRA2A (0.45) | CYP11B2SMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL7372680 | 0.80 | MAPK1 (0.48) | NPC1RAB9AKDM4EHPGDCYP2A6 | |
| SCHEMBL28766867 | 0.78 | PTGS2 (0.43) | CYP11B2SMN1; SMN2NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| CN-87105680-A | Imidazolium compounds and preparation method thereof and comprise the pharmaceutical composition of this compound | — | 1988-04-27 | — | — | CN | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |