Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374259 | 0.88 | ABL1 (0.49) | CYP11B1CYP11B2ATRALDH1A1HPGD | |
| SCHEMBL7370057 | 0.84 | LMNA (0.43) | AAK1ATRMKNK1MKNK2EGFR | |
| SCHEMBL7370838 | 0.83 | MKNK1 (0.46) | CYP11B1CYP11B2MKNK1MKNK2CYP3A4 | |
| SCHEMBL7370568 | 0.82 | CYP3A4 (0.55) | CYP11B1CYP11B2MKNK1MKNK2CYP3A4 | |
| SCHEMBL7372935 | 0.82 | ALDH1A1 (0.58) | ATRALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL7372122 | 0.81 | CYP11B1 (0.46) | CYP11B1CYP11B2MKNK1MKNK2MEN1 | |
| SCHEMBL7370764 | 0.81 | KDM4E (0.48) | CYP11B1CYP11B2HSD17B10MKNK1MKNK2 | |
| SCHEMBL7366286 | 0.81 | ABCB1 (0.49) | ATRALDH1A1MKNK1MKNK2EGFR | |
| SCHEMBL7373136 | 0.80 | POLB (0.51) | CYP11B1CYP11B2ALDH1A1HSD17B10MKNK1 | |
| SCHEMBL7372273 | 0.80 | MKNK1 (0.43) | CYP11B1CYP11B2HSD17B10MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |