Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370159 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2POLBALDH1A1GAAKDM4E | |
| SCHEMBL10615983 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBKDM4ETDP1MAPT | |
| SCHEMBL11067301 | 0.73 | POLB (0.48) | SMN1; SMN2POLBALDH1A1GAATDP1 | |
| SCHEMBL8827819 | 0.71 | SMN1; SMN2 (0.63) | SMN1; SMN2POLBALDH1A1GAAMAPT | |
| SCHEMBL11062894 | 0.71 | POLB (0.42) | SMN1; SMN2POLBALDH1A1GAATDP1 | |
| SCHEMBL9449306 | 0.71 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1GAALMNAKMT2A | |
| SCHEMBL13522913 | 0.71 | ALDH1A1 (0.51) | SMN1; SMN2POLBALDH1A1GAAKDM4E | |
| SCHEMBL14377773 | 0.69 | SMN1; SMN2 (0.60) | SMN1; SMN2POLBGAACTRB1PIN1 | |
| SCHEMBL28888471 | 0.69 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBALDH1A1GAAKDM4E | |
| SCHEMBL4047050 | 0.69 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776718-A | Reversible protease inhibitors | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |
| EP-0817778-A1 | REVERSIBLE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030353-A1 | REVERSIBLE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-10-03 | — | — | WO | disclosed |