Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338744 | 0.85 | LMNA (0.46) | SMN1; SMN2KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL6778175 | 0.79 | ITGB3 (0.45) | TSHRRECQLNTRK1NTRK2 | |
| SCHEMBL4336179 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL7350844 | 0.77 | MAPT (0.53) | SMN1; SMN2KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL7347348 | 0.74 | KMT2A (0.38) | SMN1; SMN2KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL7343852 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL7343848 | 0.74 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL7345600 | 0.73 | NPC1 (0.39) | SMN1; SMN2KMT2APOLBMAPTKDM4E | |
| SCHEMBL7369754 | 0.73 | ITGB1 (0.48) | SMN1; SMN2KMT2AMAPTLMNAMEN1 | |
| SCHEMBL7366148 | 0.73 | TSHR (0.41) | TSHRRECQLNTRK1NTRK2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |