Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414329 | 0.85 | ITGB3 (0.41) | MAPTNR1H4PPARGPPARAITGB3 | |
| SCHEMBL7379453 | 0.84 | ITGB3 (0.41) | MAPTNR1H4PPARGPPARAITGB3 | |
| SCHEMBL7453096 | 0.79 | LMNA (0.48) | MAPTLMNAMEN1KMT2ARAB9A | |
| SCHEMBL7377969 | 0.78 | KMT2A (0.51) | MAPTNR1H4ITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL7856500 | 0.75 | SENP1 (0.48) | MAPTPPARGITGB3ITGA2BLMNA | |
| SCHEMBL7452939 | 0.74 | KMT2A (0.41) | MAPTKDM4EITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL7414335 | 0.73 | NR1H4 (0.42) | MAPTNR1H4PPARGPPARAITGB3 | |
| SCHEMBL7373935 | 0.72 | NR1H4 (0.42) | MAPTNR1H4ITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL7377400 | 0.72 | MAPT (0.47) | MAPTSMN1; SMN2LMNATDP1MEN1 | |
| SCHEMBL7832432 | 0.71 | GAA (0.47) | MAPTITGB3ITGA2BSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |