Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.37 |
| ▸ | ITGAV | P06756 | 3/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379459 | 0.91 | PTGS2 (0.39) | NR1H4MAPTLMNAITGB3ITGA2B | |
| SCHEMBL7414329 | 0.86 | ITGB3 (0.41) | NR1H4MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL7377976 | 0.78 | KMT2A (0.48) | NR1H4MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL7378125 | 0.77 | ITGB3 (0.47) | NR1H4MAPTITGB3ITGA2BITGAV | |
| SCHEMBL7379453 | 0.77 | ITGB3 (0.41) | NR1H4MAPTSMN1; SMN2LMNAITGB3 | |
| SCHEMBL7378337 | 0.76 | ITGB3 (0.46) | NR1H4ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7379931 | 0.73 | ITGB3 (0.50) | NR1H4SMN1; SMN2LMNAHSD17B10ITGB3 | |
| SCHEMBL7861974 | 0.73 | ITGB3 (0.64) | NR1H4SMN1; SMN2ITGB3ITGA2BITGAV | |
| SCHEMBL7373424 | 0.73 | ITGB3 (0.64) | NR1H4SMN1; SMN2ITGB3ITGA2BITGAV | |
| SCHEMBL7376111 | 0.73 | MAPT (0.38) | NR1H4MAPTSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |