Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | F11 | P03951 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379453 | 0.91 | ITGB3 (0.41) | ITGB3ITGA2BSMN1; SMN2NR1H4LMNA | |
| SCHEMBL7414335 | 0.86 | NR1H4 (0.42) | ITGB3ITGA2BSMN1; SMN2NR1H4LMNA | |
| SCHEMBL7376111 | 0.85 | MAPT (0.38) | ITGB3ITGA2BSMN1; SMN2NR1H4LMNA | |
| SCHEMBL7453096 | 0.83 | LMNA (0.48) | LMNARAB9AMAPTKMT2AMEN1 | |
| SCHEMBL7379459 | 0.77 | PTGS2 (0.39) | ITGB3ITGA2BNR1H4LMNAJAK3 | |
| SCHEMBL7377969 | 0.76 | KMT2A (0.51) | ITGB3ITGA2BSMN1; SMN2NR1H4LMNA | |
| SCHEMBL7373935 | 0.76 | NR1H4 (0.42) | ITGB3ITGA2BSMN1; SMN2NR1H4JAK3 | |
| SCHEMBL7378120 | 0.75 | ITGB3 (0.57) | ITGB3ITGA2BSMN1; SMN2NR1H4JAK3 | |
| SCHEMBL7378327 | 0.73 | ITGB3 (0.54) | ITGB3ITGA2BNR1H4PPARGPPARA | |
| SCHEMBL7379927 | 0.72 | KMT2A (0.45) | ITGB3ITGA2BSMN1; SMN2NR1H4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |