Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10807248 | 0.84 | KDM4E (0.43) | PDE3BPDE3AKDM4EKMT2AALDH1A1 | |
| SCHEMBL10680809 | 0.83 | DRD2 (0.36) | PDE3BPDE3AKDM4EKMT2AHSD17B10 | |
| SCHEMBL10680981 | 0.81 | DRD2 (0.38) | PDE3BPDE3AMAPTDRD2GAA | |
| SCHEMBL10683067 | 0.81 | KDM4E (0.37) | PDE3BPDE3AKDM4EALDH1A1MAPT | |
| SCHEMBL7384614 | 0.81 | PDE3B (0.47) | PDE3BPDE3AKDM4EKMT2AALDH1A1 | |
| SCHEMBL7383615 | 0.81 | PDE3B (0.46) | PDE3BPDE3AKDM4EKMT2AALDH1A1 | |
| SCHEMBL7384727 | 0.81 | PDE3B (0.62) | PDE3BPDE3AKDM4EKMT2AMAPT | |
| SCHEMBL10684915 | 0.81 | CDC7 (0.40) | PDE3BPDE3AALDH1A1MAPTDRD2 | |
| SCHEMBL7381645 | 0.79 | PDE3B (0.44) | PDE3BPDE3AKDM4EKMT2AALDH1A1 | |
| SCHEMBL7385630 | 0.79 | MAPT (0.45) | PDE3BPDE3AKDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428045-A | 5-acyl-2-(1H)-pyridinoes | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5118696-A | 5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4992452-A | Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4853395-A | Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | disclosed |
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |
| US-4731371-A | Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-15 | — | — | US | disclosed |
| EP-0124090-B1 | 5-ACYL-2-(1H)-PYRIDINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |