Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 3/20 | 0.51 |
| ▸ | TUBB | P07437 | 3/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7384060 | 0.87 | SCN1A (0.45) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1436447 | 0.86 | TUBB4A (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL709048 | 0.85 | ABCG2 (0.50) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1004147 | 0.84 | RXFP1 (0.53) | ALDH1A1LMNATPMTKMT2AMEN1 | |
| SCHEMBL2486085 | 0.84 | PKM (0.62) | ALDH1A1MAPTLMNAMAPK1KMT2A | |
| SCHEMBL11229430 | 0.82 | ALDH1A1 (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1003355 | 0.80 | BRD4 (0.44) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9545203 | 0.79 | HSP90AA1 (0.61) | ALDH1A1MAPK1SCN1ASCN2ASCN3A | |
| SCHEMBL7276036 | 0.79 | KMT2A (0.49) | ALDH1A1MAPTLMNAMAPK1GFER | |
| SCHEMBL4625442 | 0.79 | TUBB1 (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486155-B1 | Method of inhibiting neoplastic cells with isoquinoline derivatives | CELL PATHWAYS INC | 2002-11-26 | — | — | US | disclosed |
| WO-1998038168-A1 | ISOQUINOLINONE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 1998-09-03 | — | — | WO | disclosed |