Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | GLI1 | P08151 | 1/20 | 0.44 |
| ▸ | GLI2 | P10070 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | EPOR | P19235 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4129755 | 0.84 | CTSL (0.47) | PTGS1MEN1KMT2A | |
| SCHEMBL5110019 | 0.83 | PTGS1 (0.67) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL30371750 | 0.81 | PTGS1 (0.64) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL7380424 | 0.81 | PTGS1 (0.68) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL6925413 | 0.80 | PTGS1 (0.62) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL8813325 | 0.80 | PTGS1 (0.62) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL11644321 | 0.79 | CYP2C19 (0.69) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL11138445 | 0.78 | PTGS1 (0.63) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL4489361 | 0.77 | PTGS1 (0.62) | PTGS1MEN1KMT2ACYP2D6ALOX5 | |
| SCHEMBL4489363 | 0.77 | PTGS1 (0.62) | PTGS1MEN1KMT2ACYP2D6ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019046-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020049316-A1 | Protease inhibitors | HALBERT STACIE MARIE (US) | 2002-04-25 | — | — | US | disclosed |
| EP-1019046-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998048799-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049316-A1 | Protease inhibitors | CTSK, CTSZ, CTSG | PTGS1 167/4885MEN1 1159/4885KMT2A 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.