Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 5/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.35 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.34 |
| ▸ | ITGAV | P06756 | 3/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377901 | 1.00 | TGM2 (0.37) | TGM2F10F2PRSS1PRSS2 | |
| SCHEMBL7377895 | 0.88 | F10 (0.38) | F10F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7376076 | 0.86 | ITGB3 (0.39) | GPR132ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7376071 | 0.86 | ITGB3 (0.39) | GPR132ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7375584 | 0.85 | ALDH1A1 (0.41) | GPR132ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7375578 | 0.85 | ALDH1A1 (0.41) | GPR132ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7378147 | 0.81 | ITGB3 (0.39) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7380590 | 0.81 | GPR132 (0.39) | GPR132ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7380583 | 0.81 | GPR132 (0.39) | GPR132ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7375604 | 0.78 | ALDH1A1 (0.39) | F10F2PRSS1GPR132ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |