Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.39 |
| ▸ | ITGAV | P06756 | 16/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375584 | 0.88 | ALDH1A1 (0.41) | ITGB3ITGAVALDH1A1ITGA2BITGB1 | |
| SCHEMBL7375578 | 0.88 | ALDH1A1 (0.41) | ITGB3ITGAVALDH1A1ITGA2BITGB1 | |
| SCHEMBL7380612 | 0.87 | ITGB3 (0.43) | ITGB3ITGAVITGA2BLMNAMAPT | |
| SCHEMBL7376071 | 0.87 | ITGB3 (0.39) | ITGB3ITGAVALDH1A1ITGA2BITGB1 | |
| SCHEMBL7376076 | 0.87 | ITGB3 (0.39) | ITGB3ITGAVALDH1A1ITGA2BITGB1 | |
| SCHEMBL7379503 | 0.81 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPT | |
| SCHEMBL7377906 | 0.81 | TGM2 (0.37) | ITGB3ITGAVALDH1A1ITGA2BITGB1 | |
| SCHEMBL7377901 | 0.81 | TGM2 (0.37) | ITGB3ITGAVALDH1A1ITGA2BITGB1 | |
| SCHEMBL7380445 | 0.79 | ALDH1A1 (0.39) | ITGB3ITGAVALDH1A1ITGA2BITGB1 | |
| SCHEMBL7380583 | 0.79 | GPR132 (0.39) | ITGB3ITGAVALDH1A1ITGA2BITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |