Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 8/20 | 0.71 |
| ▸ | KCNK9 | Q9NPC2 | 6/20 | 0.71 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.56 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11596555 | 0.86 | KCNK3 (0.59) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL2173418 | 0.85 | HTT (0.71) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL5612900 | 0.85 | KCNK3 (0.69) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL2298254 | 0.84 | KCNK3 (1.00) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL1680201 | 0.81 | KCNK3 (0.50) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL9799718 | 0.81 | PTGS1 (0.60) | KCNK3KCNK9SIRT1KMT2AMEN1 | |
| SCHEMBL363342 | 0.81 | PTPN1 (0.67) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL19491390 | 0.81 | SIRT1 (1.00) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL363881 | 0.81 | PTPN1 (0.67) | KCNK3KCNK9SIRT1RAB9ANPC1 | |
| SCHEMBL14715827 | 0.80 | KCNK3 (0.92) | KCNK3KCNK9SIRT1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087946-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065880-A1 | ARYL ALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 1999-12-23 | — | — | WO | disclosed |