SCHEMBL7380941

SCHEMBL7380941

COC(=O)[C@H](NS(=O)(=O)c1ccc(OC)cc1)c1ccccc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A3 P43003 1/20 0.54
SLC1A2 P43004 1/20 0.54
SLC1A1 P43005 1/20 0.54
MMP2 P08253 8/20 0.54
MMP9 P14780 5/20 0.54
MMP3 P08254 4/20 0.53
MMP13 P45452 4/20 0.53
MMP1 P03956 3/20 0.53
MMP8 P22894 3/20 0.53
MMP7 P09237 1/20 0.53
CA12 O43570 2/20 0.52
CA9 Q16790 2/20 0.52
CA14 Q9ULX7 2/20 0.52
ALDH1A1 P00352 4/20 0.52
POLB P06746 1/20 0.52
KDM4E B2RXH2 3/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C19 P33261 1/20 0.52
GLA P06280 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7383649 0.90 SLC1A3 (0.59) SLC1A3SLC1A2SLC1A1MMP2MMP9
Hydrochloric Acid SCHEMBL8513671 0.89 SLC1A3 (0.58) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL7373322 0.86 MMP9 (0.57) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL7373320 0.86 MMP9 (0.57) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL7024095 0.83 KDM4E (0.61) SLC1A3SLC1A2SLC1A1MMP2MMP9
SCHEMBL6323452 0.80 MMP2 (0.73) MMP2MMP9MMP3MMP13MMP1
SCHEMBL29540673 0.80 MMP2 (0.73) MMP2MMP9MMP3MMP13MMP1
SCHEMBL6323453 0.80 MMP2 (0.73) MMP2MMP9MMP3MMP13MMP1
SCHEMBL28434497 0.80 ADAMTS4 (0.57) MMP2MMP9MMP13MMP1ALDH1A1
SCHEMBL11065834 0.80 CNR1 (0.70) MMP2MMP9MMP3MMP13MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934267-B1 ALPHA-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS UPJOHN CO (US) 2002-01-30 EP disclosed
EP-0934267-A1 $g(a)-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-08-11 EP disclosed
US-5804593-A FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. PHARMACIA & UPJOHN COMPANY (US) 1998-09-08 US disclosed
WO-1998017645-A1 α-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-04-30 WO disclosed