Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 13/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830940 | 0.94 | ATM (0.53) | ATMITGB3ITGA2BHDAC8ITGA4 | |
| SCHEMBL9830929 | 0.94 | ATM (0.53) | ATMITGB3ITGA2BHDAC8ITGA4 | |
| SCHEMBL7263839 | 0.89 | ITGB3 (0.48) | ITGB3ITGA2BCTSLCTSSITGAV | |
| SCHEMBL7382971 | 0.87 | ATM (0.48) | ATMITGB3ITGA2BHDAC8CTSL | |
| SCHEMBL7385168 | 0.83 | HDAC8 (0.47) | ATMITGB3ITGA2BHDAC8CTSL | |
| SCHEMBL24795018 | 0.82 | ITGB3 (0.53) | ITGB3ITGA2BCTSLCTSSCTSK | |
| SCHEMBL4178755 | 0.82 | ITGB3 (0.53) | ITGB3ITGA2BCTSLCTSSCTSK | |
| SCHEMBL254638 | 0.82 | ITGB3 (0.53) | ITGB3ITGA2BCTSLCTSSCTSK | |
| SCHEMBL7374762 | 0.81 | MMP3 (0.43) | ITGB3ITGA2BHDAC8CTSLCTSS | |
| SCHEMBL10477854 | 0.79 | CTSK (0.50) | ATMHDAC8CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4870183-A | RENIN INHIBITORS, HYPOTENSIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| US-4857650-A | Novel renin inhibitory amino acid derivatives | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0252727-A1 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-01-13 | — | — | EP | disclosed |
| EP-0206807-A2 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-12-30 | — | — | EP | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |