Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.31 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367304 | 0.95 | APOBEC3G (0.53) | APOBEC3GNPC1LMNAPKMHTT | |
| SCHEMBL10365374 | 0.87 | APOBEC3G (0.57) | APOBEC3GPTGS2SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL9428059 | 0.81 | APOBEC3G (0.50) | APOBEC3GPTGS2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9727526 | 0.80 | APOBEC3G (0.53) | APOBEC3GNPC1LMNAHTTRAB9A | |
| SCHEMBL28840959 | 0.74 | RAB9A (0.40) | NPC1LMNAPKMHTTRAB9A | |
| SCHEMBL9429059 | 0.74 | APOBEC3G (0.39) | APOBEC3GPTGS2 | |
| SCHEMBL7362224 | 0.71 | APOBEC3G (0.61) | APOBEC3GLMNAHTTSLC6A4CYP1A2 | |
| SCHEMBL7384646 | 0.70 | LMNA (0.40) | NPC1LMNAPKMHTTRAB9A | |
| SCHEMBL9633956 | 0.70 | APOBEC3G (0.67) | APOBEC3GLMNASLC6A4LDHA | |
| SCHEMBL1903485 | 0.69 | APOBEC3G (0.59) | APOBEC3GLMNAHTTCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314887-A | Cardiovascular disorders | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-05-24 | — | — | US | disclosed |
| US-5166148-A | Treatment of congestive heart failure | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-11-24 | — | — | US | disclosed |
| WO-1992000741-A1 | 2-AMINO-1,4-DIHYDROPYRIDINE DERIVATIVES WITH CALCIUM AGONIST AND ALPHA1-ANTAGONIST ACTIVITY | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-01-23 | — | — | WO | disclosed |