Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7387231 | 0.82 | NPC1 (0.32) | LMNA | |
| Pivalate SCHEMBL7874022 | 0.79 | MEN1 (0.34) | LMNA | |
| SCHEMBL7870692 | 0.76 | MEN1 (0.31) | LMNA | |
| SCHEMBL7376958 | 0.76 | KMT2A (0.40) | LMNAALDH1A1 | |
| SCHEMBL7345230 | 0.74 | AKR1C3 (0.46) | PTGS2 | |
| SCHEMBL7379152 | 0.72 | MAOB (0.41) | LMNAALDH1A1 | |
| SCHEMBL7385350 | 0.69 | GAA (0.38) | LMNAALDH1A1 | |
| SCHEMBL8526963 | 0.66 | PTGS2 (0.43) | PTGS2LMNA | |
| SCHEMBL1930874 | 0.66 | KMT2A (0.58) | PTGS2LMNAALDH1A1 | |
| SCHEMBL29037488 | 0.65 | PTGS2 (0.42) | PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484949-A2 | Ester inhibitors | CORTECH, INC. (US) | 1992-05-13 | — | — | EP | claimed |
| US-5314910-A | 2-Heteroaromatic alkanoate esters useful as inhibitors of human leukocyte or neutrophil elastase | CORTECH INC. (US) | 1994-05-24 | — | — | US | disclosed |
| US-5240956-A | Phenyl 2-heteroaromatic-alkanoates, elastase inhibitors | CORTECH, INC. (US) | 1993-08-31 | — | — | US | disclosed |
| EP-0484949-A2 | Ester inhibitors | CORTECH, INC. (US) | 1992-05-13 | — | — | EP | disclosed |