Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870692 | 0.84 | MEN1 (0.31) | ELANEKMT2AMEN1LMNA | |
| SCHEMBL7385357 | 0.82 | PTGS2 (0.42) | LMNA | |
| Pivalate SCHEMBL7874022 | 0.78 | MEN1 (0.34) | NPC1ELANEGAAKMT2ACYP1A2 | |
| SCHEMBL7353801 | 0.75 | AKR1C3 (0.43) | ESR1HIF1A | |
| SCHEMBL7376958 | 0.75 | KMT2A (0.40) | NPC1GAAKMT2AMEN1LMNA | |
| SCHEMBL9332276 | 0.72 | CHRNB2 (0.35) | ELANEESR1HIF1A | |
| SCHEMBL7379152 | 0.71 | MAOB (0.41) | NPC1KMT2AMEN1LMNACXCR2 | |
| SCHEMBL7385350 | 0.68 | GAA (0.38) | NPC1GAAKMT2ALMNA | |
| SCHEMBL4488140 | 0.66 | AKR1C3 (0.45) | GAALMNA | |
| SCHEMBL7347806 | 0.65 | MEN1 (0.43) | GAAKMT2ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484949-A2 | Ester inhibitors | CORTECH, INC. (US) | 1992-05-13 | — | — | EP | claimed |
| US-5314910-A | 2-Heteroaromatic alkanoate esters useful as inhibitors of human leukocyte or neutrophil elastase | CORTECH INC. (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0484949-A2 | Ester inhibitors | CORTECH, INC. (US) | 1992-05-13 | — | — | EP | disclosed |