Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | REN | P00797 | 13/20 | 0.54 |
| ▸ | MMP2 | P08253 | 4/20 | 0.51 |
| ▸ | MMP9 | P14780 | 3/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | CTSD | P07339 | 5/20 | 0.49 |
| ▸ | PGA5 | P0DJD9 | 5/20 | 0.49 |
| ▸ | CTSE | P14091 | 5/20 | 0.49 |
| ▸ | PGC | P20142 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317104 | 1.00 | MEN1 (0.61) | MEN1ALDH1A1KMT2ASMN1; SMN2REN | |
| SCHEMBL8683934 | 0.86 | ALDH1A1 (0.58) | MEN1ALDH1A1KMT2AMMP2MMP9 | |
| SCHEMBL7332179 | 0.84 | MMP2 (0.51) | MEN1ALDH1A1KMT2AMMP2MMP9 | |
| SCHEMBL7332174 | 0.84 | MMP2 (0.51) | MEN1ALDH1A1KMT2AMMP2MMP9 | |
| SCHEMBL7354503 | 0.83 | MEN1 (0.48) | MEN1ALDH1A1KMT2ASMN1; SMN2REN | |
| SCHEMBL7299611 | 0.82 | ALDH1A1 (0.54) | MEN1ALDH1A1KMT2ASMN1; SMN2MMP2 | |
| SCHEMBL7346803 | 0.82 | REN (0.64) | MEN1ALDH1A1KMT2ASMN1; SMN2REN | |
| SCHEMBL9437597 | 0.82 | MEN1 (0.49) | MEN1ALDH1A1KMT2ASMN1; SMN2REN | |
| SCHEMBL9437603 | 0.81 | MEN1 (0.46) | MEN1ALDH1A1KMT2ASMN1; SMN2REN | |
| SCHEMBL4673538 | 0.81 | MMP2 (0.55) | MEN1ALDH1A1KMT2AMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5272268-A | Dipeptide derivatives | SHIONOGI & CO., LTD. (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223615-A | Hypotensive agents | SHIONOGI & CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5194608-A | Hypotensive agents; inhibits renin-angiotensin system | SHIONOGI & CO., LTD. (JP) | 1993-03-16 | — | — | US | disclosed |
| EP-0468641-A2 | Renin inhibiting dipeptide derivatives, their preparation and pharmaceutical preparations containing them | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-01-29 | — | — | EP | disclosed |