Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.64 |
| ▸ | CTSD | P07339 | 5/20 | 0.55 |
| ▸ | PGA5 | P0DJD9 | 5/20 | 0.55 |
| ▸ | CTSE | P14091 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PGC | P20142 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355315 | 0.83 | REN (0.53) | RENCTSDPGA5CTSEPGC | |
| SCHEMBL7317104 | 0.82 | MEN1 (0.61) | RENCTSDPGA5CTSEMEN1 | |
| SCHEMBL7385524 | 0.82 | MEN1 (0.61) | RENCTSDPGA5CTSEMEN1 | |
| SCHEMBL7331287 | 0.78 | REN (0.63) | RENCTSDPGA5CTSEPGC | |
| SCHEMBL7340387 | 0.78 | REN (0.53) | RENCTSDPGA5CTSEPGC | |
| SCHEMBL9680246 | 0.75 | REN (0.51) | RENCTSDPGA5CTSEPGC | |
| SCHEMBL8955003 | 0.73 | REN (0.66) | RENCTSDCTSEMEN1ALDH1A1 | |
| SCHEMBL7335450 | 0.72 | REN (0.58) | RENCTSDCTSE | |
| SCHEMBL7354503 | 0.71 | MEN1 (0.48) | RENCTSDPGA5CTSEMEN1 | |
| SCHEMBL9322207 | 0.71 | REN (0.67) | RENCTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| WO-1992022313-A1 | RENIN INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1992-12-23 | — | — | WO | disclosed |