SCHEMBL7385644

SCHEMBL7385644

O=C(COCCN1CCCCC1)CC(=O)OCCCc1ccncc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
HRH3 Q9Y5N1 9/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
LTA4H P09960 3/20 0.44
SLC6A2 P23975 2/20 0.44
HRH1 P35367 2/20 0.44
CHRM2 P08172 1/20 0.44
ADRA2C P18825 1/20 0.44
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
KCNH2 Q12809 1/20 0.44
CACNA1C Q13936 1/20 0.44
SCN5A Q14524 1/20 0.44
CHRM4 P08173 1/20 0.43
HTR2C P28335 1/20 0.43
HTR7 P34969 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7373567 0.89 SMN1; SMN2 (0.62) ALDH1A1SMN1; SMN2HRH3LTA4HSIGMAR1
SCHEMBL7906481 0.89 SMN1; SMN2 (0.62) ALDH1A1SMN1; SMN2HRH3LTA4HSIGMAR1
SCHEMBL7383210 0.88 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2HRH3L3MBTL1LTA4H
SCHEMBL7383838 0.88 CHRNA7 (0.49) ALDH1A1SMN1; SMN2HRH3LTA4HSIGMAR1
SCHEMBL7370485 0.85 MAPT (0.54) ALDH1A1SMN1; SMN2HRH3LTA4HSLC6A2
SCHEMBL7368346 0.85 HRH3 (0.60) ALDH1A1SMN1; SMN2HRH3L3MBTL1HRH1
SCHEMBL7386195 0.82 NAAA (0.45) ALDH1A1SMN1; SMN2HRH3HRH1KCNH2
SCHEMBL7368858 0.82 HRH3 (0.52) ALDH1A1SMN1; SMN2HRH3LTA4HSIGMAR1
SCHEMBL7386801 0.81 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2HRH3L3MBTL1KCNH2
SCHEMBL7372574 0.81 SIGMAR1 (0.48) ALDH1A1TMEM97SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6218538-B1 ANTAGONISTS OF N-TYPE NEURONAL CALCIUM CHANNELS USEFUL IN THE TREATMENT OF CEREBROVASCULAR ISCHAEMIA AND PAIN. ASTRA AKTIEBOLAG (SE) 2001-04-17 US disclosed
EP-0993450-A1 NEW COMPOUNDS Astra Aktiebolag (publ) (SE) 2000-04-19 EP disclosed
WO-1999001438-A1 NEW COMPOUNDS ASTRA AKTIEBOLAG (PUBL) (SE) 1999-01-14 WO disclosed