SCHEMBL7370485

SCHEMBL7370485

COc1ccc(CCCOC(=O)CC(=O)COCCN2CCCCC2)cc1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.54
POLB P06746 1/20 0.54
HRH3 Q9Y5N1 8/20 0.50
DRD2 P14416 1/20 0.48
LTA4H P09960 1/20 0.48
ACHE P22303 1/20 0.47
ALDH1A1 P00352 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CYP2D6 P10635 1/20 0.46
ESR1 P03372 1/20 0.46
ESR2 Q92731 1/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A4 P31645 1/20 0.46
SLC6A3 Q01959 1/20 0.46
SIGMAR1 Q99720 1/20 0.45
KDM4E B2RXH2 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7373567 0.87 SMN1; SMN2 (0.62) POLBHRH3LTA4HALDH1A1SMN1; SMN2
SCHEMBL7906481 0.87 SMN1; SMN2 (0.62) POLBHRH3LTA4HALDH1A1SMN1; SMN2
SCHEMBL7372574 0.87 SIGMAR1 (0.48) ALDH1A1SIGMAR1
SCHEMBL7383210 0.86 ALDH1A1 (0.64) POLBHRH3LTA4HALDH1A1SMN1; SMN2
SCHEMBL7385644 0.85 ALDH1A1 (0.48) HRH3LTA4HALDH1A1SMN1; SMN2CYP2D6
SCHEMBL7368346 0.83 HRH3 (0.60) POLBHRH3ALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL7368858 0.80 HRH3 (0.52) HRH3LTA4HALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL7537859 0.80 SIGMAR1 (0.53) MAPTPOLBHRH3LTA4HALDH1A1
SCHEMBL7383838 0.80 CHRNA7 (0.49) HRH3LTA4HALDH1A1SMN1; SMN2SIGMAR1
SCHEMBL7370951 0.78 MEN1 (0.60) HRH3LTA4HKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057332-A Substituted 1,4-dihydropyrimidine-5-carboxylate compounds, their preparation and uses ASTRA AKTIEBOLAG (SE) 2000-05-02 US disclosed
EP-0994859-A1 COMPOUNDS Astra Aktiebolag (publ) (SE) 2000-04-26 EP disclosed
WO-1999001437-A1 COMPOUNDS ASTRA AKTIEBOLAG (PUBL) (SE) 1999-01-14 WO disclosed