Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.71 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.66 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.66 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5620549 | 0.85 | TAS1R3 (0.60) | P2RX7TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL534385 | 0.83 | P2RX7 (1.00) | P2RX7TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL1987660 | 0.83 | TAS1R3 (0.64) | P2RX7TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL12181561 | 0.83 | P2RX7 (0.75) | P2RX7ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28583422 | 0.82 | P2RX7 (0.97) | P2RX7TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL23573396 | 0.81 | P2RX7 (0.67) | P2RX7ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23573395 | 0.81 | P2RX7 (0.67) | P2RX7ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3172457 | 0.81 | TAS1R3 (0.59) | P2RX7TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL4705927 | 0.81 | P2RX7 (0.71) | P2RX7TAS1R3TAS1R1TAS1R2ALDH1A1 | |
| SCHEMBL23021683 | 0.81 | P2RX7 (0.62) | P2RX7TAS1R3TAS1R1TAS1R2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138340-B2 | Bicyclononene derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-03-20 | — | — | US | disclosed |
| EP-1786814-B1 | BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-03-31 | — | — | EP | disclosed |
| US-20090306123-A1 | Bicyclononene derivaties | ACTELION PHARMACEUTICALS LTD. (CH) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306123-A1 | Bicyclononene derivaties | REN, ACE, CYP51A1 | P2RX7 1680/4885TAS1R3 4507/4885TAS1R1 3960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.